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Merck, Pfizer COVID-19 Antivirals Different From Ivermectin. Link for Richard,
https://twitter.com/richjsimmonds

https://www.factcheck.org/2021/10/scicheck-merck-pfizer-covid-19-antivirals-different-from-ivermectin/?fbclid=IwAR2YgSVzorIwnzLmtNfyBUXInsbuEw3bHf6ZVhyDlNtXp11SPL1orXz_bSs

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SciCheck Digest

The pills are very different from the antiparasitic medication ivermectin,

Dubbed PF-07321332, the investigational medication is a protease inhibitor that blocks a key enzyme the SARS-CoV-2 virus needs to replicate itself.

Molnupiravir

While the results have not been published or peer-reviewed, they were compelling enough for the trial’s independent Data Monitoring Committee to recommend an early halt to recruitment into the study.

Food and Drug Administration, an advisory committee to discuss the application on Nov. 30.

Molnupiravir is a nucleoside analog — a drug that messes up viral replication by tricking the virus into using the processed medication as one of its building blocks for its genetic code.

This is what’s known as “error catastrophe,” using a mechanism called “lethal mutagenesis.”

Although both drugs are novel, with news of these developments, people on social media are spreading the false notion that the pills are the same or “suspiciously similar” to ivermectin

Some iterations of the claim incorrectly posit that Pfizer’s drug is “based on” ivermectin and that the two are essentially the same because both are protease inhibitors

— something that has not been established, and even if true, doesn’t mean the drugs are similar,

That paper, (computational modeling paper published by some Indian scientists in March)

however, does not show that ivermectin acts as a protease inhibitor against SARS-CoV-2 through any sort of biological experiment — it only proposes the possibility based on computer simulations.

Drugs Shown to Inhibit SARS-CoV-2 in COVID-19
Open Access

Disease: Comparative Basic and Clinical Pharmacology of
Molnupiravir and Ivermectin

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf

It (ivermectin) is being repurposed as a therapeutic agent for COVID-19, after in vitro studies in Vero/hSLAM cells, showed that it caused a 5000-fold inhibition of SARS-CoV-2,

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article (Journal of antibiotics)

http://dhakes.com/wp-content/uploads/2021/08/20210615-The-mechanisms-of-action-of-Ivermectin-against-SARS-CoV-2-An-evidence-based-clinical-review-article.pdf

One such enzyme, 3 chymotrypsin-like proteases (3’cl pro/ Mpro) is responsible for working on this polyprotein causing other proteins to “librate” and carry out viral replication. Ivermectin binds to this enzyme and disrupts it.

But the same is true of PF-07321332

Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations (20th August 2021)

https://pubmed.ncbi.nlm.nih.gov/34502033/

The crystal structure of 3CLpro in complex with PF-07321332, lopinavir, and ritonavir is not yet available. Therefore, the docked complex of PF-07321332, lopinavir, and ritonavir with 3CLpro was generated using the Molecular operating environment (MOE) software.

FB post

“Looks like Merck is repackaging the ‘horse drug’ and making it much more expensive! It will be the ‘new’ treatment for C. in pill form,”

The Food and Drug Administration has warned people against self-medicating with easier-to-access formulations of ivermectin for livestock, which are highly concentrated and also may include other ingredients that have not been tested in people.

As a result, there is no basis for claiming that either the Pfizer or Merck drugs are similar to ivermectin in any way.

Pfizer also denies any connection. “Pfizer’s protease inhibitor is not similar to that of an animal medicine and is not the same mechanism,” a company spokesperson said in an email

That post uses the phrase “Pfizermectin,”

Editor’s note: SciCheck’s COVID-19/Vaccination Project is made possible by a grant from the Robert Wood Johnson Foundation.

Final fact
Fluvoxamine also has 3 fluorine atoms as does PF-07321332

Written by Dr. John Campbell

Hello Everyone,My name is John Campbell and I am a retired Nurse Teacher and A and E nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally.

Comments

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  1. So Dr. I'm a 62 year old heart attack and 6 bypasses survivor who has been very sceptical of getting the jab because of the links to Myocarditis etc. would you recommend I get the jab as long as they aspirate the needle? I'm quite healthy and am back playing football every week and am rather active for my age and would like to stay that way, I'm nervous about getting the jab.
    Cheers
    David
    PS, I love your videos but they'd never get aired on Australian mainstream media because they don't suit the propaganda campaign being waged by the governments and media companies here.

  2. Fact-checkers, you're all corrupted for censoring ppl whether or not they're right about what they're expressing. People have the right to decide for themselves. We're all adults after all. You cannot decide for others. Now, most of us know that for a pay-check you're working with the globalists who are trying to impose on humanity by taking their rights and their freedom away. Just know that the time will come. We won't forget. Yeah, go ahead and delete this one too.

  3. I followed you in the beginning when I heard Pam Acker referred you as a good Doctor speaking about Vit. D, i stopped following when you were nonchalant about the vax adverse effects…Now I am starting to realize you are authentic and always seeking truth. Bravo Doctor!

  4. That "horse" drug cured my son's high fever overnight. He didn't just feel better. It was like he'd never even been sick.

    I was prepared for him being sick for at least 3 weeks. I've never seen anything work like this beford.

    Truly amazing stuff. My ivermectin had a smiling horse on the box.

    I gave my son half the tube, which I later found out would've been the perfect dose had he weighed 600 lbs.

    Being tall and lanky it is very unlikely he weighs 600 lbs.

    However, there seems to be zero side effects from giving him 6 times the amount recommended for his weight, which is probably closer to 125 lbs rather than 600 lbs.

    I purchased my "horse" medication online by looking up animal feed stores that cater to farmers.

    I think it was around $15 per tube, which treats one 1,200 lb human, or a bunch of slender, 125 lb horses.

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