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Best ivermectin meta analysis

Ivermectin for Prevention and Treatment of COVID-19 Infection

A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

https://journals.lww.com/americantherapeutics/Abstract/9000/Ivermectin_for_Prevention_and_Treatment_of.98040.aspx

Background

The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.

A 2018 application for ivermectin use for scabies gives a direct cost of $2.90 for 100 12-mg tablets.

Most trials were registered, self-funded, and undertaken by clinicians

We assessed

Efficacy of ivermectin treatment in reducing mortality

Chemoprophylaxis

Data sources

Databases up to April 25, 2021

Sifted for studies, extracted data, and assessed risk of bias

Meta-analyses were conducted and certainty of the evidence was assessed

GRADE approach

https://training.cochrane.org/grade-approach

https://bestpractice.bmj.com/info/toolkit/learn-ebm/what-is-grade/

GRADE (Grading of Recommendations, Assessment, Development and Evaluations)

Reproducible and transparent framework for grading certainty in evidence

100 organisations worldwide officially endorsing GRADE

GRADE has four levels of evidence, certainty in evidence

very low
low
moderate
high

Decreasing confidence

Risk of bias

Imprecision

Inconsistency

Indirectness

Publication bias

Increases confidence

Very large magnitude of effect

Clear dose-response gradient

Residual confounding is likely to decrease rather than increase the magnitude of effect

Data sources

24 randomized controlled trials

N = 3,406 participants

Ivermectin reduced risk of death compared with no ivermectin

Meta-analysis of 15 trials (n = 2,438)

Average risk ratio 0.38

Moderate-certainty evidence

(Confirmed using DerSimonian–Laird method and Biggerstaff–Tweedie method)

Ivermectin verses no ivermectin in hospital patients

Ivermectin, 2.3%

No ivermectin, 7.8%

Ivermectin prophylaxis reduced COVID-19 infection

3 trials, n = 738

Average reduction 86%

Low-certainty evidence

(due to study design limitations and few included trials)

Clearly favored ivermectin use

improvement

deterioration

Severe adverse events

Rare among treatment trials

Evidence of no difference was assessed as low certainty

Conclusions

Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin.

Using ivermectin early in the clinical course may reduce numbers progressing
to severe disease.

The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

Current NIH recommendations

https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19

The sample size of most of the trials was small

Various doses and schedules of ivermectin were used

Some of the randomized controlled trials were open-label

Patients received various concomitant (confounding) medications (e.g., doxycycline, hydroxychloroquine, azithromycin, zinc, corticosteroids)

The severity of COVID-19 in the study participants was not always well described

The study outcome measures were not always clearly defined

Ivermectin for preventing and treating COVID‐19 (April, 2021)

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017/full?highlightAbstract=ivermectin%7Ccovid

Written by Dr. John Campbell

Hello Everyone,My name is John Campbell and I am a retired Nurse Teacher and A and E nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally.

Comments

  1. 99.99% of people survive covid and ivermectina helps 85% of these 1% recover what's going on wake up talk about it and stand together we can stop it

  2. Note: Since this video, the 2020 Elgazzar study, which accounted for just over a tenth of this meta-analysis's data and had the most favourable results, has been retracted.

  3. We shall celebrate 24TH JULY 2021 , with gratitude for miracle drug IVERMECTIN and wonder drug NAC – Capt Ajit Vadakayil. Search & Read More details read in Captain Ajit Vadakayil blogspot.

  4. What I find interesting is that it takes over a year to come out with studies of ivermectin while it only took 8 mos to produce a new technology RMNA medication. If the governments of this world truly were as interested in ALL cures of covid wouldn't they go full speed on all studies etc. ? This is in my opinion shows wide scale corruption.

  5. I am so glad Dr. Campbell is asking the question all of us should be asking, that is, why are the health agencies like the CDC, WHO, etc. silent about Ivermectin as a complement to the vaccines, given all these evidences of its effectiveness as a safe prophylatic and therapeutic drug? WHY???

  6. The million dollar question is why is fauci still blocking use of ivermectin claiming its not effective treatment for covid? I bet this doctor won't touch this question lol

  7. Is it true that spineless accademics are nurturing a bad result as a recent new studdy has been rightly attacked for falsifying ivermectin data in a negative way .

  8. Caught Covid the last week of the school term 16th July. I am double vaccinated and still felt really ill. I managed to get my hands on Ivermectin and took it when things got really bad. I had a very high temp, massive headache, painful eyes, burning sinus and pain in the bones. At one point I was shivering so much I could not get warm and it was 28 C, the pain was unbelievable so I took the Ivermectin with yogurt. Within 1/2 an hour of taking it the shivering stopped and the pain was reduced by 90% and I fell asleep for 6 hours. I took it again 12 hours later so it worked out twice a day for 4 days then I had a break of 4 days. By Wed I thought I was in the clear but by Thursday lunch time I was coughing so much my head was hurting, again I took the medication, fell asleep for 4 hours and woke up not coughing. I am going to take another dose on Sunday if needed.

  9. An email I received today from a US trusted health source………………

    Today is World Ivermectin Day!

    Tune in live right now to hear the testimonials of doctors and scientists around the world who are saving lives with this medicine. Happening all day today at:

    http://www.worldivermectinday.org

    There now 60 trials, 39 of them already peer-reviewed, involving 21,874 patients and 574 scientists, proving without a doubt that Ivermectin effectively treats THAT THING THAT'S GOING AROUND (TTTGA).

    Collectively these trials show 85% improvement for prevention, 74% improvement for early treatment, and 43% improvement for late treatment. This is not drug company science. This is science conducted by heroic independent doctors and researchers around the world, with no financial incentives to promote this medicine.

    See the science here

    Ivermectin is one of the safest anti-parasitic, antiviral, anti-inflammatory medicines in the world (safer than aspirin), with over nearly 4 billion doses given since its development in 1975. Dr. Satoshi Omura won the Nobel Prize in Medicine for its discovery. He identified and isolated the active compounds from soil bacteria in Japan.

    Ivermectin is the solution!

    One of my favorite examples, in a trial in Argentina, one group of 800 healthcare workers were given Ivermectin prophylactically (as a preventative measure), none got TTTGA. Another group of 400 healthcare workers were not given Ivermectin. Over half of that group got TTTGA.

    FLCCC supplement protocol for prevention

    -Vitamin D 1,000-3,000 IU per day (I take 5,000 – 10,000 per day)

    -Vitamin C 1,000 mg twice per day

    -Quercetin 250 mg per day

    -Zinc 30-40 mg per day

    -Melatonin 6 mg before bedtime

    This FLCCC web page tells you exactly how to take Ivermectin. The dosage is based on your body weight. There are prevention, early treatment and hospitalization protocols, and an I-RECOVER protocol for "long" symptoms and post-shot symptoms.

    Here is a directory of doctors that will prescribe Ivermectin with an online, phone or text consultation.

    My wife has taken it with zero side effects. And I have some on hand just in case.

    Ivermectin is also available in a liquid paste for horses on Amazon and at farm feed stores like Tractor Supply.

    Ivermectin also targets multiple cancer pathways. Check out this study.

    To your life and health!

  10. The latest research available on the BIRD website https://bird-group.org/bayesian-meta-analysis-of-ivermectin-confirms-bryant-et-al-study-that-ivermectin-works-for-covid/ says this:

    A new analysis from Queen Mary, University of London confirms the conclusions of the Bryant et al, 2021 Meta Analysis that Ivermectin has a markedly positive effect on treating covid and casts serious doubt on the conclusions of Roman et al, 2021.

    It cites probability ratios in favour of Ivermectin of up to 90.7% for treating patients with covid and a 50% reduction in the probability of death.

  11. Sorry Dr John the most cited study is a non study. It never took place. Presented Plagiarized data, fake charts totally debunked in peer review as fake.. Will you stop this. After all yourexcellen work you prormote ivermectun (all other studies were retroactive meta studies. CHECK IT.

  12. Please recommend vaccines & stop this nonsense. Ivermectin MAY reduce severe disease. That study has been wuthdrawn. Promite moniclonaks fir treatment or better vaccines. Check it.

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