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ENACT trial | A Study That Makes Pharma Rich and Patients’ Poor | I break it down

Vinay Prasad, MD MPH; Physician & Associate Professor

Google Scholar: https://scholar.google.com/citations?user=ym4rwk0AAAAJ&hl=en
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Personal Website: www.vinayakkprasad.com
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Podcast Website: www.plenarysessionpodcast.com
Academic Publications: http://www.vinayakkprasad.com/papers

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  1. LP reacted d ryt way, she is Kayantanii.UNO need of over drama, or over consider ations. She don't deserve *considerationsm. Lp പറഞ്ഞ പോലെ,, ജീവിതം തുടങ്ങിയല്ലേ ഉള്ളു, പഠിക്കട്ടെ.

  2. something you didn't go over that I think is worth mentioning, this study enrolled over 200 people, the cost must have been incredibly high given how expensive this medicine is.

  3. LP reacted d ryt way, she is vym.Monster need of over drama, or over consider ations. She don't deserve *considerationsr. Lp പറഞ്ഞ പോലെ,, ജീവിതം തുടങ്ങിയല്ലേ ഉള്ളു, പഠിക്കട്ടെ.

  4. Dr Prasad, how do we stop the nonsense especially when Faucci or Bill Gates like sales agents misleading the public, yet go on receiving awards and beaming in arrogance ,after a charade of congressional hearing?

  5. Dubious endpoints, egregious cost, and experimenting with the lives of men on active surveillance. We know monotherapy with ADT leads to the development of resistance as does therapy with ASI drugs like enzalutamide. They are putting men on active surveillance at risk for enzalutamide side effects of hypertension, reduced seizure threshold, fatigue, falls, and cognitive impairment. And trials show that men treated with enzalutamide monotherapy developed high testosterone levels, resulting in a significant proportion developing gynecomastia and breast tenderness due to peripheral aromatization. The PSA spike upon discontinuation of enzalutamide should doom this study. What do you tell the scared trial participants then? Whoops! Such a dumb study. Pfizer, the PIs, and doctors who signed up their patients should be embarrassed.

  6. Would you be able to take the slides and move them to fullscreen, and then put your video feed in the corner or side? I watch this on my phone and its just too small to see the slides! You are very handsome, so don't feel bad, but I would appreciate if you increased the screen real-estate dedicated to the visual aids.

    Also, I'm a postbac applying for MSTP right now. I love the show and it's helping me form an interest in oncology and health policy. I really like how you seem so honest. Lots of medical and science news seems stuffy and obscure, but your attitude is so infectious that I can't help but get excited about sticking it to the man and doing really good studies one day. Btw, when I'm writing papers, I'm never ever going to use a medical writer!

  7. I have a feeling those that are making decisions in the FDA would be willing to give big pharma the go ahead. Since when do they worry about cost.

  8. I truly admire your persistence. It seems prudent to offer you credence given your motive is highly laudable. Perhaps you should take a leap into the cell structure of a particle wave as it relates to the replication sequence. Water flowing from a tap may look crystal clear but would it not be a fatal leap to state it is void of contaminants? Examine the dilution rate as it pertains to the enhancement of an antibody in the structural depth of a vaccine. The war is already over doctor. Our lives are vacuous of substance and enrichment because we choose to live this way.

  9. Even if the benefit of this drug does not justify the $100k cost as of the time of this study, is it not true that competition with a similar androgen inhibitor / economies of scale in production of the drug / generic versions being produced will eventually lower the cost massively? At least in theory it makes sense to approve a drug (that is actually effective/safe) without regards to cost, because once the drug is approved, there will eventually be market forces that bring down the cost.

  10. What is the most common age for developing prostate cancer? I'm not in the medical field. My only experience with this cancer is a relative who was diagnosed in his 70s, in the 1970s, and died from it at age 85, in the 1980s. At that time, as his children told me then, there was no treatment, but it was slow growing, so he just continued living his life, enjoying every moment, and putting his affairs in order. I was also told that it was most common in elderly men. If that's the case, then why pursue immortality? I don't mean to be crass, but death comes to all, one way or other. That doesn't mean forget all medical care or healthy practices. It just means that at some point it's a quixotic exercise of futility trying to stay alive, especially considering the negative side effects that severely impact quality of life. Maybe some Howard Hughes zillionaire wants to live forever…let that one buy this drug.

  11. Medicine and the FDA is being run by Big Pharma. Adudelm, the blockbuster, or should I state Medicare Buster drug approved by the FDA for Alzheimer disease will increase Medicare costs by 50% and is singularly useless in AD treatment.

  12. This is another reason why med onc is the worst specialty of medicine. A year's worth of RT on beam is far more effective for cure, safer and cheaper than a single course of Pembrolizumab.

  13. Are medical writers the same as "face checkers"?
    Thank-you for exposing the "fraud" and encouraging folks to take their health in their own hands (exercise, eat healthy, spiritual life…)
    Covid was an eye opener…

  14. Plagiarism is allowed now, so I don't see how having someone else write a paper should be frowned on. If you don't like it, just get your medical care in a country where they don't do that kind of thing.

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