Short excerpt
We have read with interest the recent cases suggesting the possibility of vaccine-induced
immune-mediated hepatitis with Pfizer-BioNTech and Moderna mRNA-1273 vaccines for
the SARS-CoV-2 virus.1–7 However, as the cohort of vaccinated individuals against
COVID-19 increases, the previously reported cases could not exclude a coincidental
development of autoimmune hepatitis, which has an incidence of 3/100,000 population
per year.8 Our case demonstrates conclusive evidence of vaccine-induced immune-mediated
hepatitis with a rapid onset of liver injury after the first Moderna dose, which on
re-exposure led to acute severe autoimmune hepatitis.
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