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Ivermectin, more evidence

Follow the evidence, wherever it leads

Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database

https://bnf.nice.org.uk/medicinal-forms/remdesivir.html

https://list.essentialmeds.org

https://www.sciencedirect.com/science/article/pii/S1201971221009887#
https://www.sciencedirect.com/science/article/pii/S1201971221009887
https://www.sciencedirect.com/journal/international-journal-of-infectious-diseases/vol/116/suppl/S

Purpose

To evaluate the difference in mortality,

Patients treated with ivermectin

Patients treated with remdesivir

44 healthcare organizations and 68 million patients from US,

January 1, 2020 and July 11, 2021

Methods & Materials

Retrospectively identified diagnosed adults
Recorded use of ivermectin, but not remdesivir

Recorded use of remdesivir, but not ivermectin

Controlled for, comorbidities, and treatments that may affect COVID-19 survival outcomes: age, gender, race, ethnicity, nicotine use diabetes mellitus, obesity, chronic lower respiratory disease, ischemic heart diseases, tocilizumab, glucocorticoids, or ventilator use.

Primary outcome assessed, mortality

Sith significance assessed at p less than 0.05.

Result

41,608 patients who had COVID-19

Treated with ivermectin n = 1,072

Treated with remdesivir n = 40,536

Ivermectin was associated with reduced mortality vs remdesivir
OR 0.308

p less than 0.0001.

Conclusion

Ivermectin use was associated with decreased mortality in patients with COVID-19 compared to remdesivir.

In the future, if more publications are published with the similar result to the current analyses, the certainty of evidence will increase.

Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching (Brazil)

https://www.cureus.com/articles/82162-ivermectin-prophylaxis-used-for-covid-19-a-citywide-prospective-observational-study-of-223128-subjects-using-propensity-score-matching

Background

Ivermectin has demonstrated different mechanisms of action, coronavirus infection and COVID-19-related comorbidities.

Prophylaxis combined with the known safety profile of ivermectin

Study to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.

Prospective, July 2020 and December 2020

Inviting the entire population of Itajaí to a medical visit to enroll in the program,

ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day.

Study analysis consisted of comparing ivermectin users with non-users using cohorts

Results

223,128 citizens of Itajaí considered

159,561 included in the analysis

113,845 (71.3%) regular ivermectin users

45,716 (23.3%) non-users

Of these

4,311 ivermectin users were infected, (3.7% infection rate)

3,034 non-users (6.6% infection rate)

A 44% reduction in COVID-19 infection rate

Risk ratio (RR), 0.56

The regular use of ivermectin led to a 68% reduction in COVID-19 mortality

Deaths

25 (0.8%) deaths in the ivermectin group

79 (2.6%) among ivermectin non-users

RR, 0.32

p less than 0.0001

When adjusted for residual variables, reduction in mortality rate was 70%

There was a 56% reduction in hospitalization rate

44 in the ivermectin group

99 in non ivermectin users

After adjustment for residual variables, reduction in hospitalization rate was 67%

p less than 0.0001
Conclusion

In this large study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.

Written by Dr. John Campbell

Hello Everyone,My name is John Campbell and I am a retired Nurse Teacher and A and E nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally.

Comments

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  1. I and my 71 year old mother took Ivermectin when we got covid, symptoms were gone within a day and a half, while 2 roommates declined "horse paste" – they were both extremely sick for over 2 weeks, one had to go to hospital, she was vaccinated, while the other unvaxxed, got through it at home but it was rough.

  2. Remember that Dr that treated thousands of covid patients with ivermectin g + vitamins, even severe covid cases and what do they do? Fire her 🤦🏽‍♂️

  3. Dr. John Campbell must have lost his marbles.
    Case Fatality Rate after Mechanical Ventilation for SARS CoV 2 is 45% (PMID: 33119402).
    How the hell can this moron compare a 1% IMV cohort of n=1000 to a 2% IMV cohort of n=40,000???
    The mortality ratio will be twice as high. Not to mention that remdesivir EUA specifically states that it is not to be used under those circumstances!!!
    John Campbell do you digest this idiotic paper BEFORE you cited it???
    Good lord this is like watching a train wreck of stupidity.

  4. The evidence of the first study is not very good, age difference and different severity of Infection… Also, the drug ivm is compared to is sucpectwd to cause a lot more harm than good anyway.

  5. Wait, what?!! I don't think you know what you are talking about
    How can you compare people who took ivermectin to those who took remdesivir without bias? People who take remdesivir are already hospitalized and very sick, since it is only IV and indicated only sick people with COVID 19. Any person can be prescribed ivermectin at home, even if they are asymptomatic. It is called selection bias.

  6. Good on you Honest John, you've never shied away from reporting on the so called "dangerous pseudo Covid treatments" nor have you ever parroted the narrative, although you cleverly, cautiously pulled your punches, not only did it keep you in the fight, impartiality made you so perfectly palatable to refer you to the lesser-informed sceptic. Strategically kept you enough under radar, that it enabled you to keep informing.

    Though too late for millions of victims of suppression & deception, so relieved that not only front line doctors who called for Ivermectin are vindicated, that the truth is coming out.

    I & my family have taking Ivermectin since mid 2020, on a risk appropriate basis, as prescribed by our doctor. Brilliant!

  7. Got mine sitting on the table will use so far so far I am a walking disaster health wise I take my vitmanD vitamin C zinc so far I have never caught been exposed to it before sometimes I think it just forgot about me can’t figure that one out grandson had I was with him boy had but wasn’t around him much he wouldn’t come over was around my physical therapist that had what’s your take on that Doc?

  8. Robert Kenned Jr., in his recent book "The Real Anthony Fauci", pointed out that, at least in the USA, emergency use authorization for the COVID 19 vaccines depended on there being no other available drug that could treat the disease. If there were available treatments, the new vaccines would have to go through very long trial processes before they could be approved.

  9. New Zealand has made IVM illegal to import. It gets seized at the border. We have some compounding pharmacies making it (for $3.00/pill) but one pharmacy that I ordered from with a doctor's prescription just emailed me the following:

    "Thank you for email. Unfortunately we have been contacted by Medsafe and have had all our Ivermectin materials held at the border. We have reviewed the pharmacy council advise and we will no longer be dispensing this medication at all.

    Please go back to your Doctor and see if there are other alternatives."

    I would love it if you could bring attention to this. NZ working hard to keep IVM from its citizens. If it's cheap and safe I don't know why we don't have a right to try it. It's very disturbing.

  10. I am a cardiologist in the US. I love your videos and I recommend them to my extended family and friends when I want to get a point across. I have gotten them to take vitamin D and zinc and I think most of them are vaccinated. None of us has gotten more than a sore throat or runny nose. Thank you for your clear presentations and valuable information. Evidence, not dogma.

  11. When ivermectin info first started turning up, I looked up side effects online and discovered it was very safe. I looked it up again a few days ago and now it appears that ivermectin is very dangerous. How does it all get changed like that? Makes me distrust everything the medical sites say…

  12. 16:16. "I mean, the people who took Ivermectin got less infections, they were hospitalised much less, and they died much less. What is not to like"? But I cannot purchase Ivermectin in Estonia.

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