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Ivermectin or Molnupiravir

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Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf

https://www.linkedin.com/in/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38/

There are still many nations where vaccines are not yet widely available,

There is a gradual shift in focus, to antiviral drugs,

Adjunctive chemoprophylaxis

Active treatment of new SARS-CoV-2 infections

Post -vaccination breakthrough COVID-19 cases

The two ways to get new drugs

Develop novel antiviral drugs for SARS-CoV-2

Repurpose existing FDA -approved drugs to treat COVID-19

Ivermectin is the most studied “repurposed” medication globally,

in randomized clinical trials, retrospective studies and meta- analyses.

Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics

Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,

seasonal or pandemic influenza and MERS corona virus

Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic

and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

https://www.sciencedirect.com/science/article/pii/S0166354220302011

5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours

The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.

Both molnupiravir and ivermectin are well absorbed after oral dosing

Tmax of molnupiravir being 1-1.75 hours,

With a half life of 7 hours

Tmax of ivermectin is 4-6 hours

Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution

Ivermectin has the ability to accumulate in the lungs

The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent

Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA

causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication

There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells

Ivermectin, multifarious actions,

Binding to SARS-CoV-2 spike protein S

Reducing cell entry via human ACE2 receptors

Reducing viral transcription

Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)

Complimentary pharmacokinetics and pharmacodynamics of the drugs

May be additive or synergistic

This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.

A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.

Cost

https://www.who.int/selection_medicines/committees/expert/21/reviews/Ivermectin_Review1.pdf

The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.

Say, 12mg per day for 5 days = $0.53

Safety

http://www.vigiaccess.org

https://www.who-umc.org/vigibase/vigibase/

Efficacy

Ivermectin

https://pubmed.ncbi.nlm.nih.gov/34145166/

For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence

https://ivmmeta.com

Early treatment

Late treatment

Prophylaxis

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/epdf/full

Main results, Treating people in hospital with COVID-19

We don’t know whether ivermectin compared with placebo or usual care, 28 days after treatment:–

leads to more or fewer deaths

worsens or improves patients’ condition assessed by need for ventilation or oxygen

increases or reduces unwanted events

Preventing COVID-19

We don’t know whether ivermectin leads to more or fewer deaths compared with no drug

Written by Dr. John Campbell

Hello Everyone,My name is John Campbell and I am a retired Nurse Teacher and A and E nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally.

Comments

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  1. Dr. Campbell – thank you for researching sharing research studies from around the globe! Even under normal circumstances, the US media is very US centric; now with COVID, it's obvious there is additional effort to suppress and belittle information that does not follow the US narrative.

  2. Many of you are aware of the controversy involving Aaron Rodgers, quarterback for the Green Bay Packers, who tested positive for COVID. He has been vilified by the press following an interview for taking Ivermectin and other measures in lieu of being vaccinated. They took his comments about being “immunized” as being a sham, lying, inconsiderate of others and believing in phony homeopathic medicine. I sense that most of these folks are in the “woke” group of hypocrites. I am a retired eye doc and did extensive post-graduate training and certification in therapeutic pharmacology. I responded to these indignant “journalists” and explained the efficacy of Ivermectin in treating covid and cited studies like Dr. Campbell has done in this video. But I also threw in Hydroxychloriquine, which is also a cheap drug that has been available for decades. As an immunomodulator it can be effective in suppressing the cytokine storm in early ARDS (the pneumonia that causes significant morbidity in covid patients). We do not need politics to dictate treatment protocols that are best left to medical providers and their patients.

  3. As far as I can see ivermectin was shown to be effective in three places: 1. fabricated studies; 2. meta-analyses that include fabricated studies; and 3. studies that only look at its effect on the coronavirus in the lab, while in studies that have looked at its effect on actual people it doesn't seem to work.

    I'm happy to be wrong about all this, but I don't yet see the evidence. Care to comment?

  4. If reviewing the benefits of both drugs, it is clear that both drugs due provide benefits in reducing the Viral reproduction but Ivermectin has the added benefit of reduction of cytokine and anti-inflammatory effects. The length of drug effectiveness is outstanding at 81-91 hrs and the cost is under a $1 per avg Treatment.

    This makes this ideal for Poorer countries or for Countries where Costs of Medicine is high.

    We saw how Ivermectin was ordered to be used across the entire country of India when they started to have exploding cases of Covid. The action to use Ivermectin in Home kits along with treating positive cases early caused the 90% reduction in Positive Cases that The WHO refused to acknowledge and is why the India Bar Assoc. Is Sueing the Head of the WHO for claiming the cause is a mystery to deny that Ivermectin was the reason for the 90% reduction…

  5. My indian supplier can no longer send Ivermectin to the UK. I tried to order a second batch as my current batch goes out of date in January 2022. They told me due to the large volume of their packages being confiscated by Uk customs they can no longer sell to the UK. So, the Government who knows Ivermectin is effective is doing everything it can to stop people getting hold of them. Its an evil act as far as Im concerned.

  6. The new WHO clinical trial process is : Theorise and test numerous treatments. Throw out clinical trial data of any treatment that is off licence so money cant be made with it. Check bank balance for kickback monies. Authorise distribution and advise global government only to use medications from companies providing the biggest kickbacks. Buy shares in funeral providers as deaths rack up. For those with no morals it’s a big win. So sad but this is what we can expect from the new global governance we are all being consigned to.

  7. I am not a doctor, but… it has been proven that when Zinc get into your cells it stops viral reproduction… Quercetin is taken with Zinc, it helps the zinc enter cells and if a very effective way to protect yourself from any virus.

  8. I can't believe that healthcare organization would rather give an unproven vaccine, instead of IVERMECTIN. Which has been proven to work and would safe life, IVERMECTIN it's been around for years, it has won the noble prize yet many doctors don't even know what it is…..I shocked at our health care, of the stupidity and negative focus on the vaccine, which does not work in the end.

  9. Love your work.
    Careful with these synthetic Lactones like Ivermectin. They are very useful but over use is harmful, like all drugs. Resistance develops very quickly and the pass through the body largely unchanged. Extremely toxic to aquatic systems. Used with care, very effective.
    Stay healthy everyone. 😀

  10. Haha, great. Ivermectin for horses and pigs sold out in Germany and Austria. Austria at 1000 inc. now having another lockdown. Additional cases of overdosing of Iverm. caused bad cramps until blood pressure drops and knockouts. Seems Ivermecshit just works in braindead fantasies.

  11. It is CRIMINAL THAT WE HAVE BEEN CHEATED ON THE TREATMENT AND AVAILABILITY OF IVERMECTIN,ESPECIALLY NOW THE JABS ARE NOT KILLING OFF THE VIRUS, IVERMECTIN WOULD, 2 tears too late, I have been writing and forwarding videos to my MP. AND HEALTH SERVICES FOR 18 months CRIMINAL NEGLECT COMES TO MIND ON THOUSANDS OF DEATHS IN UK ALONE.

  12. Has anyone heard of the YouTube channel "How Much"?
    It tells you how much you favorite your over make a per month and this per year from the views ( not counting super chats or patreon.
    VERY INTERESTING!

  13. To all who do not want to believe in the efficacy of ivermectin, that is your choice. We who have used and benefited from ivermectin, will continue to use it and be better from it. Ivermectin is cheap and safe. You prefer molnupiravir which is much more expensive and unproven safety, that’s your choice. Big pharma loves you.

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