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Low vitamin D and increased deaths

Lower levels of vitamin D, higher rates of death

Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496747/

Observational study, non-interventional

Background

Vitamin D, lower levels, common in patients with cardiovascular disease (CVD)

Study of patients with existing CVD

Prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with,

All-cause mortality and,

cause-specific mortality

Methods

N = 37,079 patients with CVD from the UK

Biobank study

From a prospective cohort of half a million, aged 40–69 years

https://www.ukbiobank.ac.uk

CVD

Coronary heart disease

Atrial fibrillation

Heart failure

Stroke

Results

Among 37,079 patients with CVD at baseline, 57.5% were vitamin D deficient

Deficient, 25[OH]D less than 50 nmol/L (less than 20ng/ml)

Median follow-up of 11.7 years

Deaths that occurred = 6,319 total

2,161 deaths from CVD

2,230 deaths from cancer

623 deaths from respiratory disease

1,305 other-cause deaths

Non-linear inverse associations

For all-cause mortality

Cancer mortality

Respiratory disease mortality

Other-cause mortality

That is deaths went up as vitamin D levels went down

(P-non-linearity less than 0.01)

Approximately linear inverse associations for CVD

That is deaths went up as vitamin D levels went down

(P-non-linearity = 0.074)

Among CVD patients with vitamin D deficiency

For every 10 nmol/L increment in serum 25(OH)D concentrations,

There was an associated 12% reduced risk for all-cause mortality

There was an associated 9% reduced risk for CVD mortality.

In patients with vitamin D deficiency

Per 10 nmol/L increase in serum 25(OH)D levels,

was associated with a lower risk of mortality from (aHR]; 95% CI)

All-cause 0.88

CVD 0.91

Cancer 0.90

Respiratory diseases 0.81

Other causes 0.81

Multivariable Cox regression models

Age, sex, alcohol, BMI, GFR, education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol

Conclusion

Among patients with existing CVD,

increasing levels in serum 25(OH)D,

were independently associated with a decreased risk of all-cause and cause-specific mortality

These findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.

Therefore

Patients with vitamin D deficiency may benefit more from an increase in serum levels,

than those with CVD and serum 25(OH)D levels of less than 50 nmol/L (less than 20ng/ml)

Our findings provided novel clues
awaiting further validation in clinical trials.

Written by Dr. John Campbell

Hello Everyone,My name is John Campbell and I am a retired Nurse Teacher and A and E nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally.

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  2. The benefit curve does not consider all the other parts of the body that are dependent on vitamin D. A curve examining GENERAL HEALTH VS vitamin D would be more indicative of how necessary this critical substance is to the health of the body.

  3. Dear Dr. John
    I would like to thank you a lot for all the efforts and time that you spent in doing such helpful and interesting lectures, you are amazing teacher.
    I would like to ask if you can give a full course of pathophysiology.
    As we are medical students we are really need your help in explaining pathophysiology.
    Kind regards

  4. A. U.S. Senator Dr. Paul claims Gov-Covid Director Faucy caused this epidemic.
    B. UK reportedly exposed the unaccepted practice of KEY VAX contracts.
    C. U.S. Fed-CT-STAY-&~66% house-Dems against firing anyone for refusing these vaccines.
    D. What's left but Inherited National NATURAL Immunities–INNI–reported before-these-vaccines.
    E. TOP-10-INNI-Nations did harbor the Lowest-World covid Fatalities prior to these vaccines:

    %-Fatal. Nov-2/Jan-31 Feb-7/11 Jun-7 ~Mid-Sumr Oct-14 Oct-20 Nov-8/2021

    CAYMN 0.49-0.50 0.50 0.38 0.37 0.29 0.20 0.07
    NZ 0.97 0.95-0.89 0.59 0.54 0.41
    SYCL 0.26 0.39-0.44 0.36 0.42-0.52 0.55 0.55 0.54
    DUBAI 0.28 0.31 0.29 0.29 0.29 0.29 0.29
    BHRN 0.36 0.35-6 0.42 0.51-0.50 0.50 0.50 0.50
    MLDV 0.32 0.32-3 0.26 0.28-0.29 0.28 0.28 0.28
    SNGPR 0.05 0.05 0.05 0.06-0.07 0.14 0.16 0.23
    MONGL 0.09-10 0.25 0.47 0.45 0.46 0.41 0.49
    ICLND 0.48 0.45 0.45-0.32 0.27 0.26 0.24
    BUTN 0.12 0.11

    WORLDWIDE identified INNI-NATIONS by VIA A FEW KEY CATEGORIES, LIKE:

    1. *Virus-Free-Islands or peninsulas*, like Cayman Island, Singapore, NZ, Maldives.
    2. *Virus-Free COLD-CLIMATES*, like Iceland, Mongolia, Norway, Alaska.
    3. Virus-Free-High-Residences-Near-Beaches,-Lakes e.g. NZ, Iceland, Israel, Estonia, Ethiopia.
    4. *Virus-Free-ARID-ZONES-DESERTS-DUNES*,-like in Dubai, Bahrain, Mongolia, Uzbekistan, etc.
    5 *BORDERS-TO-ALL-NATIONS-CLOSED-PRIOR-TO-VAX-MANDATES*, cf. SINGAPORE, NZ.
    6. Minor INNI-variations inside countries differ substantially *between*, up to 20 in Yemen.
    7. INNI reduces relative-*Wave-Amplitudes-by-Virus-Attacks*, recorded by-MAX-NUMBERS/TRENDS.
    8. WHO should publish Virus-Diffusion RATES via square-roots across all borders, discussed elsewhere.
    9. This factual scientific study is neither a conspiracy theory nor anti-verified-vaccination per se.

    The-Next top-16-INNI-NATIONS-did-harbor-less-than-1.00%-FATALITIES-prior-to-this-vaccine-era:

    %-Fatal. Nv-2/Jn-31 Fb-7/11 Jun-7 ~Mid-Sumr Oct-14 Oct-20 Nov-8/2021

    VNZL 0.94-5 0.94 1.13 ~1.14 1.21 1.20 1.20
    TWN 0.88 0.96-7 1.02 1.66-4.96-5.22 5.18 5.15
    ISRL 0.74 0.74 0.76 0.71 ~0.68 0.61 0.61 0.61
    CYPRS 0.64 0.67 0.68 0.42 ~0.50 0.47 0.47 0.46
    Bora-Bora 0.73 0.73-4 0.75 0.66~0.75 1.57 1.58 1.58
    NORWY 0.75 0.62 ~0.61 0.45 0.45 0.43
    SRLNK 0.49 0.50-2 0.80 1.69~1.32 2.54 2.54 2.54
    MLASIA 0.36 0.36 0.37 ~0.41 0.98 1.17 1.17
    St-VNC 0.25-0.45 0.59 ~0.54 0.93 1.36
    ARUBA 0.86 0.86-0.91 0.97 0.87~0.96 1.09 1.08 1.07
    CUBA 0.85 0.72-4 0.68 0.77~0.69 0.86 0.86 0.86
    TLND 0.43 0.33-4 0.68 0.78~0.83 1.03 1.00 1.00
    TIMOR 0.06 ~0.05 0.11 0.11 0.62
    DNMRK 0.89 0.89 ~0.78 0.68
    USBKS 0.79-8 0.73 ~0.68 0.71
    CURCO 0.46 0.46-8 ~0.99 1.02

    The pan-situation may be understood by ALL NATIONS reports to WHO since 2020, e.g.:

    %-Fatal. Nov-2/Jan-31 Feb-7/11 Jun-7 ~Mid-Sumr Oct-14 Oct-20 Nov-8/2021

    MEXICO 8.48-8.51 8.59-61 9.41 9.29~8.03 7.58 7.57 7.57
    ITLY 5.45-3.51 3.46-7 2.99 2.99~2.90 2.79 2.79 2.75
    CHINA 5.39-5.20 5.17 5.09 5.05~4.91 4.81 4.80 4.74
    SUDAN 4.78-2.09 6.92 6.95~7.47 7.54 7.68 7.70
    UK 4.51-2.77 2.83 2.84 ~ 2.72 1.67 1.63 1.52
    CANAD 4.30-2.57 2.58 1.85 1.85~1.86 1.70 1.69 1.69
    AUSTRL 3.28-3.16 3.15 3.15 ~3.14 2.98 1.11 1.01
    DNMRK 2.11-1.44 1.06 0.89 ~0.86 0.73 0.73 0.68
    GRMNY 2.56-1.84 2.71-6 2.42 2.42~2.44 2.19 2.17 2.04
    U.S. 2.51-1.74 1.60 1.79 ~1.79 1.80 1.62 1.64

    PERU 9.41 ~9.41 9.20 9.08
    SYRIA 6.68 7.24 7.35~7.36 6.26 6.15 5.96
    EQDOR 5.26 4.81 6.45~4.74 6.41 6.41 6.35
    GRC 3.70 3.60-5 2.99 3.00~2.46 2.23 2.20 1.98
    HNGRY 3.40 3.52 3.71 ~3.71 3.65 3.63 3.50
    TUNIS 3.48 3.67 ~3.63 3.53 3.54
    GTMLA 3.41 3.19 ~3.10 2.43 2.43 2.54
    S-AFR 3.42 3.39 3.14~3.04 3.04 2.96 3.06
    INDNSI 2.56 ~2.71 3.21 3.38 3.38
    COLMB 2.59 2.60 2.52~2.54 2.55 2.55 2.54
    BLGUM 2.53 2.34 2.20 ~2.32 2.03 2.00 1.85

    ROMNIA 2.47 2.82 3.01~3.16 2.89 2.87 2.97
    BRAZIL 2.89- 2.55 2.43-5 2.79 ~ 2.79 2.79 2.79 2.79
    ARGNT 2.43 2.06 ~2.10 2.19 2.19 2.19
    FRNCE 2.69-2.45 2.39 2.38-9 ~1.93 1.92~1.73 1.66 1.64
    CHILI 2.24 2.11 ~2.08 2.26 2.25 2.22
    PHLP 2.11 1.71 1.71 ~1.74 1.49 1.50 1.58
    SPN 2.06 2.10 2.17 2.14~1.76 1.74 1.74 1.74
    SWDN 2.04 2.04-6 1.31 1.32~1.35 1.28 1.28 1.28
    PRTGL 1.70 1.89 2.00 1.96~1.75 1.68 1.72 1.66
    SWIS 1.80 1.80-1 1.55 1.55~1.49 1.31 1.30 1.27
    PKSTN 2.15 2.20 ~2.33 2.22 2.24
    UKRAIN 2.31 2.31 2.34~2.35 2.35 2.31 2.34
    RUSSIA 1.94-5 2.41 2.41~2.58 2.62 2.79 2.81
    INDIA 1.11 1.19 1.21~1.33 1.33 1.33 1.34
    More at https://www.linkedin.com/feed/update/urn:li:activity:686150945892169728

  5. Here in Germany they are now beginning to put Vitamin D in Products out of Business – it's in the news everywhere – one might come to some Conclusion why…

  6. I watched your video Sir super analysis … medical and health awareness program is very good …plz making videos continuously Sir ..you are best in health guidance Sir🇮🇳 I am from India Sir 🇮🇳

  7. Sir vitamin D 100 level is good best for health and 125 up bad to health less 100 ..75 is low level is not good for health …I understood Sir … How much vitamin D level should a normal person? Normal people?🇮🇳 Generally ..🇮🇳 if vitamin D level low 75 mortality risk high …. supplementry medicine serums good or not Sir?

  8. I have long suffered from SAD starting in November, however for the past two years, having taken Vit D as recommended by Dr John, I have noticed that I haven’t suffered either this month or in Nov 2020.

  9. They do not study the 50ng/ml which is the study to make. Vitamin D3 blood level alone may be much more effective then any vaccine. And that's only vitamin D. Then if you go to optimize further natural immunity we may be able to leave covid19 behind. These vaccines are for the vulnerable people with low immunity. Mass vaccination probably kills natural immunity!

  10. If every one had a reasonable vitamin d level hospitals would be empty, PHARMA would suffer. I use it since almost 10 year, high dos and never had a flu or something like a flu. It works.

  11. Most tropical countries like India have enough sunlight and that's why they have enough Vitamin D still their government recommended Vitamin D and Zinc for people. I saw the ICMR list it was there right from the start. In US not a single time Vitamin D was mentioned, only vaccines are being pushed.

  12. This one is pharma corp puppet. Don't believe me. Try to silence/report on him. You will still receive his crap. Same time you barely find or see something about Peggy Hall. Or "vacccine companies are exempt from liabilities" movement. Just try it. And learn to distinguish truth from pharma corporate puppets.

  13. New real data on VItamin D– Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs

    Jie Chen, Kaibo Mei, Lixia Xie, Ping Yuan, Jianyong Ma, Peng Yu, Wengen Zhu, Chunhua Zheng & Xiao Liu

  14. So If I take vitamin D, is there ever a stopping point? Like can I take the recommended daily dose every day and keep taking it daily or do I need to stop taking it as some point?

  15. I have been taking vitamin D for 15months approx and multivits and minerals and pre biotics probiotics . I have not had a cold for 2 years now nor sinusitis which I have have on frequent occasions over the years in the past

  16. I can’t be the only one believing the media pushes unhealthy ads on us like Pepsi and Coca Cola or fast food and sugary candies waiting for the majority of us to slip into an unhealthy diet or even addiction, then drops a virus on us and the only solution is a vaccine to keep us from death since most of us have some internal issue because we ate too much sugar or cholesterol. And then after we all take the vaccine they tell us “well you can still transmit it and die, there’s just a smaller window”. Now that we got you all to do what we planned, here is what we lied about.

    The government and media are a bunch of slippery snakes, I don’t know how anyone trusts them.

  17. Oh the irony of the powers that be telling people to remain indoors to avoid covid. Indoors and away from the sun. And yes, the studies on vitamin D are true. Our bodies need vitamin D more than people could ever imagine…

  18. Be very careful with vitamin D. Too much can cause bone pain, calcium toxicity in the blood, cause kidney stones and be fatal to people with kidney disease. Moderation in all things.

  19. I am 79 and live in Idaho, so not much sunshine I stoped taking perscription meds 50 years ago best thing I ever did for myself. some times a battle with Doctors just have to find one that understands you won't give in to there pills and stand firm . At any age you still need as close to a good primary Dr. We have a good relationship and understanding. I have taken meds for Brongitus (spelling) if i get sick over the years a few times. , no flu shots , no Covid experamental shot . A Dr here in Idaho recommended to the public to take D,C, and zinc {he has cought hell this past year from the State med people } a 2nd doctor here has Perscribed for us Covid meds if we where to get sick with the china flu (Covid) my Dr tested my D level way up . This site is wonderfull , the comments help so much to inforce that we are not alone in the choices we make . Best to all and thank the many that comment. Jack

  20. talking about vit d def, this info maybe useful to
    anyone seeking more input into the possible/probable/actual relating to this subject matter … of all the data i have collected

    here is an exerpt from that data, hence the quotation marks…
    if you find this info useful or interesting,then pass it on, you will never get info like this through mainstream media …

    "Because the chemtrails are sprayed ABOVE the natural weather system, they block out/diffuse vital rays from the sun,including VITAMIN D,meanwhile underneath this chemical milky white sky ,the weather that normally dissipates actually BUILDS UP into freak and massive storms, flooding, hail and snowstorms that are not NORMAL, even EFFECTING NORMAL LIGHTENING PATTERNS right up to sprite level… flocks of birds are falling out of the sky because they fly into fresh chemtrails … The sun is vital to life on earth because this rock would be a dead fire without it, and thats why the volcanos are activating too, the
    chemtrails are causing them to.eventually there will be megadeath all around the world if you do not stop these lunatics" … … …end of

  21. Why has the government not
    Taken action to promote
    Vitamin D? Because vitamin D is cheap there is no money for the
    Drug company's its a world wide
    Disgrace indicative of the problem
    The system as a whole

  22. Great study results ..which i firmly beleive show conclusive evidence taking Vitamin D is like taking
    Cod Liver oil when i was a kid …very important for an older guy like me to take . I dont get colds
    i dont get the flu ..plus most of my aches and pains have gone after 8 months on D3&K2 .

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