Magnetically controlled protein NCs for intravenous injection to deliver drugs at the desired site

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Video abstract of an original research “Magnetically controlled protein nanocontainers (NC) as a drug depot for the hemostatic agent” published in the open access journal Nanotechnology, Science and Applications by Prilepskii, Schekina and Vinogradov.

Purpose: Currently, there is a number of successfully implemented local hemostatic agents for external bleedings in forms of wound dressings and other topical materials. However, little has been done in the field of intravenous hemostatic agents. Here, we propose a new procedure to fabricate biocompatible protein nanocontainers (NCs) for intravenous injection allowing magneto-controllable delivery and short-term release of the hemostatic agent ϵ-aminocaproic acid (EACA).

Conclusion: The ability of synthesized NCs to deliver and release the therapeutic drug, as well as to accumulate at the desired site under the action of the magnetic field was proved experimentally.